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Reduction in Neural-Tube Defects After Folic Acid Fortification in Canada
NEJM 357:135-142, De Wals,P.,et al, 2007
See this aricle in Pubmed

Article Abstract
Food fortification with folic acid was associated with a significant reduction in the rate of neural-tube defects in Canada. The decrease was greatest in areas in which the baseline rate was high.
 
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anencephaly
encephalocele
folic acid
neural tube defect
prenatal
prevention of neurologic disorders
spina bifida
vitamin deficiency
vitamin supplementation

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